BIOINFORMATICS TOOLS FOR NGS-BASED IDENTIFICATION OF SINGLE NUCLEOTIDE VARIANTS AND LARGE-SCALE REARRANGEMENTS IN MITOCHONDRIAL DNA

Bioinformatics Tools for NGS-Based Identification of Single Nucleotide Variants and Large-Scale Rearrangements in Mitochondrial DNA

The unique features of mitochondrial DNA (mtDNA), including its circular and multicopy nature, the possible coexistence of wild-type and mutant molecules (i.e., heteroplasmy) and the presence of nuclear mitochondrial DNA segments (NUMTs), make the diagnosis of mtDNA diseases particularly challenging.The extensive deployment of next-generation seque

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Reverse-Order Multi-Objective Evolution Algorithm for Multi-Objective Observer-Based Fault-Tolerant Control of T-S Fuzzy Systems

In this study, a multi-objective H2/H∞ observer-based fault-tolerant control (FTC) design with reverse-order multi-objective evolution algorithm (MOEA) is proposed to deal with the FTC problem of Takagi-Sugeno (T-S) fuzzy systems.To achieve the optimal robust FTC design for the T-S fuzzy systems under the sensor and actuator faults, as well

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Analysis of Gravel Migration Patterns During Vibration Rolling and Their Impact on GCL Performance Based on DEM

In this study, a multilayer composite rolling model consisting of a rolling wheel, a protective layer, a GCL, and a support layer was constructed by the discrete element method (DEM).Soil compaction and gravel migration, and their effects on the GCL, were analyzed from a fine viewpoint, and three key indexes for the safety assessment of the GCL wer

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